Minipig에서 외과적으로 형성한 일벽성 치주 결손부에 이식한 macroporous biphasic calcium phosphate (MBCP(R)) 와 fluorohydroxyapatite(Algipore(R))의 조직학적 평가
Histologic evaluation of macroporous biphasic calcium phosphate(MBCP(R)) and flouorohydrxyapatite(Algipore(R)) in surgically created 1-wall periodontal intrabony defects of minipigs
이중석, 채중규, 조규성, 최성호, 김종관, 정의원, 김창성, 채경준,
소속 상세정보
이중석 ( Lee Jung-Seok ) - 소속확인중
채중규 ( Chai Jung-Kui ) - 연세대학교 치과대학 치주과학교실
조규성 ( Cho Kyoo-Sung ) - 연세대학교 치과대학 치주과학교실
최성호 ( Choi Seong-Ho ) - 연세대학교 치과대학 치주과학교실
김종관 ( Kim Chong-Kwan ) - 연세대학교 치과대학 치주과학교실
정의원 ( Jung Ui-Won ) - 소속확인중
김창성 ( Kim Chang-Sung ) - 연세대학교 치과대학 치주과학교실
채경준 ( Chae Gyung-Joon ) - 소속확인중
KMID : 0363020070370010125
Abstract
Periodontal regenerative therapy and tissue engineering on defects destructed by severe periodontitis need maintaining of space, which provides the environment for cell migration, proliferation and differentiation. Application of bone grafts may offer this environment in periodontal defects. This study evaluated bone graft materials, and , in surgically created i-wall periodontal intrabony defects of minipigs by histological analysis. Critical sized(), one wall periodontal intrabony defects were surgically produced at the proximal aspect of mandibular premolars in either right and left jaw quadrants in four minipigs. The control group was treated with debridement alone, and experimental group was treated with debridement and and application. The healing processes were histologically observed after 8 weeks and the results were as follows. 1. In the control group, limited new bone formation was observed. 2. In MBCP group, more new bone formation was observed compared to other groups. 3. Histologically, dispersed mixture of new bone, biomaterial particles and connective tissue were shown and osteoblasts, osteoclasts and new vessels were present in this area. 4. Defects with Algipore showed limited new bone formation and biomaterial particles capsulated by connective tissue. 5. Histologically, lots of osteoclasts were observed around the biomaterial but relatively small numbers of osteblasts were shown. Within the limitation to this study protocol, application in 1-wall intrabony defect enhanced new bone formation rather than application.
키워드
periodontal intrabony defect;macroporous biphasic calcium phosphate;fluorohydroxyapatite
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